Current Issue : January - March Volume : 2021 Issue Number : 1 Articles : 5 Articles
This work aimed to assess the skin-beneficial properties of Agastache rugosa Kuntze, an herbal medication used to treat different\ntypes of disorders in traditional folk medicine. The total phenolic compounds and total antiradical, nitrite scavenging,\nsuperoxide scavenging, antielastase, and antihyaluronidase activities of a hot water extract of A. rugosa Kuntze leaves (ARE)\nwere spectrophotometrically determined. Intracellular reactive oxygen species (ROS) was fluorometrically quantitated.......................
Cosmeceutical formulations containing naturally derived active ingredients are currently\npreferred by consumers worldwide. Mushrooms are one of the potential sources for cosmeceutical\ningredients but relevant research is still lacking. In this study, hot- and cold-water extractions\nwere performed on four locally-cultivated mushrooms--Pleurotus ostreatus, Ganoderma lucidum,\nAuricularia polytricha and Schizophyllum communeâ??with the aim to assess the cosmeceutical potential\nof these mushroom fruitbody extracts. Total phenolics, polysaccharide and glucan content were\ndetermined. Antioxidant property of the mushroom extracts was assessed by determining the\nDPPH radical scavenging, ferric-reducing (FRAP) and superoxide anion (SOA) scavenging activity.\nAnti-hyaluronidase activity was used as an indicator for the anti-aging and anti-inflammatory\nproperty, while anti-tyrosinase activity was evaluated to assess the anti-pigmentation or whitening\nproperty of these extracts. ...................................
The World Health Organization estimates that 7 million people die every year due to pollution exposure. Among the different\npollutants to which living organism are exposed, ozone (O3) represents one of the most toxic, because its location which is the\nskin is one of the direct tissues exposed to the outdoor environment. Chronic exposure to outdoor stressors can alter cutaneous\nredox state resulting in the activation of inflammatory pathways. Recently, a new player in the inflammation mechanism was\ndiscovered: the multiprotein complex NLRP1 inflammasome, which has been shown to be also expressed in the skin. The\ntopical application of natural compounds has been studied for the last 40 years as a possible approach to prevent and eventually\ncure skin conditions. Recently, the possibility to use blueberry (BB) extract to prevent pollution-induced skin toxicity has been\nof great interest in the cosmeceutical industry. In the present study, we analyzed the cutaneous protective effect of BB extract in\nseveral skin models (2D, 3D, and human skin explants). Specifically, we observed that in the different skin models used, BB\nextracts were able to enhance keratinocyte wound closure and normalize proliferation and migration responses previously\naltered by O3. In addition, pretreatment with BB extracts was able to prevent ozone-induced ROS production and\ninflammasome activation measured as NRLP1-ASC scaffold formation and also prevent the transcripts of key inflammasome\nplayers such as CASP1 and IL-18, suggesting that this approach as a possible new technology to prevent cutaneous pollution\ndamage. Our data support the hypothesis that BB extracts can effectively reduce skin inflammation and be a possible new\ntechnology against cutaneous pollution-induced damage....
In previous studies, Perilla frutescens pomace was shown to contain bioactive phenolic\ncompounds and good anti-oxidative activity. However, reports about collagenase activity and\nmelanogenesis inhibitory effects of P. frutescens pomace are limited. This study aimed to evaluate the\nbioactivity of P. frutescens pomace extract and incorporate the extract into a cosmetic formulation for\nevaluating its effects on collagenase and melanogenesis inhibition on human skin. The P. frutescens\nseeds after an oil pressing process were extracted with ethanol (70% v/v) in order to examine\nthe remaining phytochemical compounds, the bioactivity in pomace perilla, and its efficacy as\na skincare product. In this study, total phenolic and total flavonoid contents of P. frutescens\nseed extract (PFSE) were determined using spectrophotometry. The free radical scavenging\nactivity was determined with.........................
Sulfated polysaccharides prepared from marine algae are potential ingredients in\nnutraceutical, pharmaceutical, and cosmeceutical industries. In the present study, the antioxidant,\nanti-melanogenesis, and photoprotective effects of sulfated polysaccharides obtained from\nEcklonia maxima (EMC) were investigated to evaluate their potential in cosmetic. EMC was successfully\nprepared through Celluclast-assisted extraction and ethanol precipitation, and it contained 79.88%\nof sulfated polysaccharides that with 69.37% carbohydrates and 10.51% sulfate. EMC effectively\nsuppressed 2,2-azobis(2-amidinopropane) hydrochloride (AAPH)-induced oxidative stress in vitro in\nVero cells and in vivo in zebrafish. Furthermore, EMC significantly inhibited mushroom tyrosinase\nand reduced melanin synthesis in alpha-melanocyte-stimulating hormone-stimulated B16F10 cells.\nIn addition, EMC remarkably attenuated photodamage induced by UVB irradiation in vitro in\nhuman keratinocytes (HaCaT cells) and in vivo in zebrafish. Furthermore, EMC effectively inhibited\nwrinkle-related enzymes and improved collagen synthesis in UVB-irradiated human dermal fibroblasts\n(HDF cells). These results indicate that EMC possesses strong antioxidant, anti-melanogenesis,\nand photoprotective activities, and suggest that EMC may be an ideal ingredient in the pharmaceutical\nand cosmeceutical industries....
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